国产肏屄视频网站_2014av天堂影音先锋_欧美一级网站视频_亚洲欧美国产日韩字幕手机版_欧美性爱免费播放_老师色诱我好爽视频免费软件_激情小说亚洲_在线观看日韩一三区_在线观看mv的免费网站_国产午夜精品懂色

姝¤繋鐎忚鎴戝徃缍�(w菐ng)绔�?銆�?/div>
涓婚爜  > 鏂拌仦涓績  > 琛屾キ(y猫)鍕曟厠(t脿i)  > PNAS锛氶噸澶х獊鐮�锛佸埄鐢≧NA鏍搁叾寰�(f霉)鍒跺拰鎿�(ku貌)澧濺NA
琛屾キ(y猫)鍕曟厠(t脿i)
PNAS锛氶噸澶х獊鐮�锛佸埄鐢≧NA鏍搁叾寰�(f霉)鍒跺拰鎿�(ku貌)澧濺NA
鏅�(sh铆)闁�: 2019-06-18 10:19鐎忚娆℃暩(sh霉)锛�1379

2016骞�8鏈�17鏃�/鐢熺墿璋稡IOON/--RNA鑷垜寰�(f霉)鍒舵槸RNA涓栫晫鍋囪鐨勪竴鍊嬮棞(gu膩n)閸甸儴鍒�锛屼絾鏄湪瀵�(sh铆)椹�(y脿n)瀹や腑鐢�(ch菐n)鐢熻兘澶犲悎鎴�銆佸京(f霉)鍒跺拰鎿�(ku貌)澧炲姛鑳芥€NA鍒嗗瓙鐨勬牳閰讹紙ribozyme锛変竴鐩存槸姣旇純鍥伴洠鐨勩€傚湪姝や箣鍓�锛屾渶鐐烘垚鍔熺殑I椤濺NA鑱氬悎閰舵牳閰惰畩鐣伴珨鍗充究鍦ㄥ畠鍊戝亸濂界殑妯℃澘---鐭殑绨″柈鐨勫瘜鍚槯鍟跺牽鍩虹殑RNA搴忓垪---涓婏紝宸ヤ綔鏁堢巼骞朵笉楂樻晥銆�

鍦ㄤ竴闋�(xi脿ng)鏂扮殑鐮旂┒涓�锛屼締鑷編鍦嬫柉鍏嬮噷鏅柉鐮旂┒鎵€鐨勭爺绌朵汉鍝″牨(b脿o)閬撲粬鍊戝埄鐢ㄩ珨澶栭€�(j矛n)鍖栫敘(ch菐n)鐢熶竴绋敼閫�(j矛n)鐨勮仛鍚堥叾鏍搁叾锛岄€欑ó鑱氬悎閰舵牳閰惰兘澶犲悎鎴愬绋姛鑳芥€х殑绲�(ji茅)妲�(g貌u)鍖朢NA鍜屾摯(ku貌)澧炵煭鐨凴NA妯℃澘銆傜浉闂�(gu膩n)鐮旂┒绲�(ji茅)鏋滀簬2016骞�8鏈�15鏃ュ湪绶氱櫦(f膩)琛ㄥ湪PNAS鏈熷垔涓婏紝璜栨枃妯�(bi膩o)椤岀偤鈥淎mplification of RNA by an RNA polymerase ribozyme鈥�銆�

 

璜栨枃浣滆€匞erald Joyce鍜孌avid Horning鍒╃敤I椤濺NA鑱氬悎閰舵牳閰剁殑涓€绋畩鐣伴珨闁嬪闁嬪睍鐮旂┒銆備粬鍊戦毃鍚庡湪瀹冪殑鏁村€嬪簭鍒椾笂寮曞叆闅ㄦ(j墨)绐佽畩锛屽緸鑰岀敘(ch菐n)鐢�100钀剟鍊嬭畩鐣伴珨銆侸oyce鍜孒orning闅ㄥ悗閫氶亷璁撻€欎簺鏍搁叾璁婄暟楂斿暉鍕曞悎鎴怰NA閬╅厤楂旓紙RNA aptamer锛�---绲�(ji茅)鍚堝埌缍敓绱燘12鐨勪汉宸ュ悎鎴愬舰寮忔垨GTP涓婄殑鍒嗗瓙---渚嗙郸閫欏€嬭畩鐣伴珨缇ら珨鏂藉姞澹撳姏銆傚湪姣忚吉绡╅伕鏅�(sh铆)锛岀爺绌朵汉鍝¢伕鎿囩敘(ch菐n)鐢熷姛鑳芥€х敘(ch菐n)鐗┿€佹纰洪暦搴︾殑鐢�(ch菐n)鐗╂垨鑰呮甯搁暦搴︾殑鍔熻兘鎬х敘(ch菐n)鐗╃殑鏍搁叾璁婄暟楂�銆�

 

鐮旂┒浜哄摗閫氶亷璁撻€欎簺鏍搁叾璁婄暟楂斿湪鏇村皯鐨勬檪(sh铆)闁撳収(n猫i)鍚堟垚鏇撮暦鐨凴NA鍒嗗瓙渚嗗鍔犻毃鍚庣閬哥殑鍤�(y谩n)璎�(j菒n)鎬�銆傚埌绗�24杓檪(sh铆)锛岄€欏€嬫牳閰惰畩鐣伴珨缇ら珨鑳藉鍚堟垚鍑哄瘜鍚槍鍛ゅ牽鍩虹殑鍔熻兘鎬NA搴忓垪銆�

 

鐮旂┒浜哄摗寰為€欏€嬬兢楂斾腑鍒嗛洟鍑轰竴绋绋变綔24-3鐨勬牳閰惰畩鐣伴珨锛屽畠鎿佹湁17鍊嬬獊璁娿€傞€欑ó24-3鑱氬悎閰舵牳閰朵娇鐢ㄤ簡鎵€鏈夌殑鍥涚ó鍫垮熀锛岃兘澶犳瘮鍒濆鐨勮仛鍚堥叾鏍搁叾鏇村揩鍦扮櫦(f膩)鎻姛鑳姐€傚畠鑳藉寰�(f霉)鍒跺绋叿鏈夊京(f霉)闆滀簩绱氱祼(ji茅)妲�(g貌u)鐨勫姛鑳芥€NA锛屽寘鎷仼閰嶉珨銆佸叾浠栫殑鏍搁叾鍜岄叺姣峵RNA銆備粬鍊戣瓑瀵�(sh铆)24-3涔熻兘澶犲湪PCR锛堣仛鍚堥叾閺�?zh菙n)妞掔;?y墨ng)锛夋妧琛�(sh霉)鐨勫儏浠NA鐐烘ā鏉跨殑鐗堟湰涓憟鎸囨暩(sh霉)绱氬湴?c谩i)U(ku貌)澧炵煭鐨凴NA妯℃澘銆�

 

渚嗚嚜鑻卞湅閱�(y墨)瀛�(xu茅)鐮旂┒鐞嗕簨鏈冨垎瀛愮敓鐗╁(xu茅)瀵�(sh铆)椹�(y脿n)瀹ょ殑Philipp Holliger锛堟湭鍙冭垏閫欓爡(xi脿ng)鐮旂┒锛夊湪鐧�(f膩)绲︺€婄瀛�(xu茅)瀹躲€嬮洔蹇楃殑闆诲瓙閮典欢涓閬�锛屸€滃畠鐪熷湴鏄潪甯镐笉閷殑鐮旂┒锛屾槸瀵�(sh铆)鐝�(xi脿n)RNA鑷垜寰�(f霉)鍒剁洰妯�(bi膩o)涓婄殑涓€闋�(xi脿ng)閲嶅ぇ閫�(j矛n)灞�銆傗€�

 

鐒惰€�锛岄€欑ó24-3鑱氬悎閰舵牳閰朵笉鑳藉鑷垜寰�(f霉)鍒躲€傜洝绠¢叺姣峵RNA鏄珮搴︾祼(ji茅)妲�(g貌u)鍖栫殑锛岃€屼笖涔熸瘮鏃╁墠鐨勮仛鍚堥叾鏍搁叾鍚堟垚鐨勭敘(ch菐n)鐗╁ぇ涓€浜�锛屼絾鏄€欑ó24-3鏍搁叾瑕佹瘮閰垫瘝tRNA澶�3鍊�锛岀敋鑷冲惈鏈夋洿鍔犲京(f霉)闆滅殑绲�(ji茅)妲�(g貌u)鍏冧欢銆�

 

Joyce銆丠orning鍜屽悓浜嬪€戝湪姝e湪閫�(j矛n)琛岀殑楂斿閫�(j矛n)鍖栧(sh铆)椹�(y脿n)涓姫鍔涘厠鏈嶉€欏€嬮檺鍒�銆傜爺绌朵汉鍝¤锛屾洿鍔犲毚(y谩n)鏍肩殑绡╅伕绛栫暐鎳�(y墨ng)鐣�(d膩ng)淇冮€�(j矛n)閫欑ó鏍搁叾鏇村姞楂樻晥鍦板埗閫犳洿鍔犲ぇ鐨�銆佹洿鍔犲京(f霉)闆滅殑鍔熻兘鎬х敘(ch菐n)鐗�銆�